Abstract
The design, synthesis, and structure-activity studies of a novel series of BK B(1) receptor antagonists based on a 1-benzylbenzimidazole chemotype are described. A number of compounds, for example, 38g, with excellent affinity for the cynomolgus macaque and rat bradykinin B(1) receptor were discovered.
MeSH terms
-
Animals
-
Benzimidazoles / chemical synthesis*
-
Benzimidazoles / chemistry
-
Benzimidazoles / pharmacology*
-
Bradykinin B1 Receptor Antagonists*
-
Combinatorial Chemistry Techniques
-
Dogs
-
Drug Design
-
Molecular Structure
-
Rats
-
Structure-Activity Relationship
Substances
-
Benzimidazoles
-
Bradykinin B1 Receptor Antagonists