Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound

H R Pfaendler; R Weishaupt; H Meffert

doi:10.1016/s0960-894x(00)00248-1

Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound

Bioorg Med Chem Lett. 2000 Jun 19;10(12):1389-91. doi: 10.1016/s0960-894x(00)00248-1.

Authors

H R Pfaendler¹, R Weishaupt, H Meffert

Affiliation

¹ Department of Chemistry, University of Munich, Germany. hrp@orf.chemie.uni-muenchen.de

PMID: 10890171
DOI: 10.1016/s0960-894x(00)00248-1

Abstract

The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of beta-lactam hydrolysis and their biological activities, particularly their beta-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology
Carbapenems / chemical synthesis*
Carbapenems / chemistry
Carbapenems / pharmacology*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Carbapenems