Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group

MeSH terms

• Catechol O-Methyltransferase / chemistry
• Catechol O-Methyltransferase Inhibitors*
• Drug Design
• Enzyme Inhibitors / chemistry*
• Enzyme Inhibitors / pharmacology*
• Indicators and Reagents
• Magnesium / chemistry
• Models, Molecular
• Molecular Conformation
• Nitro Compounds / chemistry*
• Structure-Activity Relationship