New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1665-1670. doi: 10.1016/j.bmcl.2015.03.028. Epub 2015 Mar 18.

Abstract

The phytochemical investigation of a Tunisian plant Atriplex portulacoides (Chenopodiaceae) led to the isolation of two new compounds designated as portulasoid (2) and septanoecdysone (3) along with the known 20-hydroxyecdysone (20HE) (1). Their chemical structures were elucidated on the basis of extensive spectroscopic methods including ES-HRMS, 1D and 2D-NMR. The isolated compounds were finally tested for their antioxidant activity by using DPPH, ABTS(+), Fe(3+) and catalase assays and also for their antibacterial and anticholinesterase activities.

Keywords: 20-Hydroxyecdysone; Atriplex portulacoides; Biological activities; Chenopodiaceae; NMR; Portulasoid; Septanoecdysone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Atriplex / chemistry*
  • Atriplex / metabolism
  • Cholinesterases / chemistry
  • Cholinesterases / metabolism
  • Ecdysterone / analogs & derivatives*
  • Ecdysterone / chemistry*
  • Ecdysterone / metabolism
  • Ecdysterone / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Protein Binding

Substances

  • Antioxidants
  • Plant Extracts
  • septanoecdysone
  • Ecdysterone
  • Cholinesterases