Multi-target-directed ligands to combat neurodegenerative diseases

J Med Chem. 2008 Feb 14;51(3):347-72. doi: 10.1021/jm7009364. Epub 2008 Jan 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholinesterase / metabolism
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / metabolism
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Binding Sites
  • Calcium Channel Blockers / chemistry
  • Calcium Channel Blockers / pharmacology
  • Calcium Channel Blockers / therapeutic use
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacology
  • Chelating Agents / therapeutic use
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology
  • Cholinesterase Inhibitors / therapeutic use
  • Humans
  • Huntington Disease / drug therapy
  • Huntington Disease / metabolism
  • Ligands
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / metabolism
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology
  • Neurofibrillary Tangles / metabolism
  • Neurofibrillary Tangles / pathology
  • Neurotransmitter Agents / metabolism
  • Parkinson Disease / drug therapy
  • Parkinson Disease / metabolism
  • Plaque, Amyloid / metabolism
  • Plaque, Amyloid / pathology

Substances

  • Amyloid beta-Peptides
  • Antioxidants
  • Calcium Channel Blockers
  • Chelating Agents
  • Cholinesterase Inhibitors
  • Ligands
  • Neurotransmitter Agents
  • Acetylcholinesterase