Abstract
A series of benzodiazepine inhibitors of the MMPs and TACE has been developed. These compounds display an interesting selectivity profile and should be useful tools for exploring the biological relevance of such selectivity.
MeSH terms
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ADAM Proteins
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ADAM17 Protein
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Benzodiazepines / chemical synthesis
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Benzodiazepines / pharmacology*
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Cartilage / drug effects
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Cartilage / enzymology
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Hydroxamic Acids*
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Indicators and Reagents
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Matrix Metalloproteinase Inhibitors*
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Metalloendopeptidases / antagonists & inhibitors*
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Protease Inhibitors / chemical synthesis
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Protease Inhibitors / pharmacology*
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Pyrazines*
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Structure-Activity Relationship
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Sulfonamides
Substances
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CGS 27023A
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Hydroxamic Acids
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Indicators and Reagents
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Matrix Metalloproteinase Inhibitors
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Protease Inhibitors
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Pyrazines
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Sulfonamides
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Benzodiazepines
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ADAM Proteins
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Metalloendopeptidases
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ADAM17 Protein