Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

Dawei Ma; Wengen Wu; Guoxin Yang; Jingya Li; Jia Li; Qizhuang Ye

doi:10.1016/j.bmcl.2003.10.026

Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

Bioorg Med Chem Lett. 2004 Jan 5;14(1):47-50. doi: 10.1016/j.bmcl.2003.10.026.

Authors

Dawei Ma¹, Wengen Wu, Guoxin Yang, Jingya Li, Jia Li, Qizhuang Ye

Affiliation

¹ State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China. madw@mail.sioc.ac.cn

PMID: 14684295
DOI: 10.1016/j.bmcl.2003.10.026

Abstract

The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Hydroxamic Acids / chemistry*
Hydroxamic Acids / pharmacology
Matrix Metalloproteinase Inhibitors*
Matrix Metalloproteinases / metabolism
Sulfonamides / chemistry*
Sulfonamides / pharmacology
Tetrahydroisoquinolines / chemistry*
Tetrahydroisoquinolines / pharmacology

Substances

Enzyme Inhibitors
Hydroxamic Acids
Matrix Metalloproteinase Inhibitors
Sulfonamides
Tetrahydroisoquinolines
Matrix Metalloproteinases