Abstract
Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally scarce catechin derivatives.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Catechin / analogs & derivatives*
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Catechin / chemical synthesis
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Catechin / chemistry
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Catechin / pharmacology
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Chemistry, Organic / methods
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Chemistry, Pharmaceutical / methods
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Drug Design
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Humans
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Inhibitory Concentration 50
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Matrix Metalloproteinase 1 / metabolism
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Matrix Metalloproteinase 7 / metabolism
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Methylation
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Mice
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Models, Chemical
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Recombinant Proteins / chemistry
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Stereoisomerism
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Tea
Substances
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Recombinant Proteins
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Tea
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Catechin
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epigallocatechin gallate
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Matrix Metalloproteinase 7
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Matrix Metalloproteinase 1