Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production

J Med Chem. 1998 May 21;41(11):1745-8. doi: 10.1021/jm970849z.

Authors

C B Xue¹, X He, J Roderick, W F DeGrado, R J Cherney, K D Hardman, D J Nelson, R A Copeland, B D Jaffee, C P Decicco

Affiliation

¹ The DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, Delaware 19880-0500, USA.

PMID: 9599225
DOI: 10.1021/jm970849z

No abstract available

MeSH terms

Crystallography, X-Ray
Humans
Hydroxamic Acids / blood
Hydroxamic Acids / chemical synthesis*
Hydroxamic Acids / chemistry
Hydroxamic Acids / pharmacology
In Vitro Techniques
Lactams / blood
Lactams / chemical synthesis*
Lactams / chemistry
Lactams / pharmacology
Lipopolysaccharides / blood
Lipopolysaccharides / pharmacology
Lymphocyte Activation
Matrix Metalloproteinase 1
Matrix Metalloproteinase 9
Matrix Metalloproteinase Inhibitors
Metalloendopeptidases / antagonists & inhibitors*
Metalloendopeptidases / blood
Models, Molecular
Protease Inhibitors / chemical synthesis*
Protease Inhibitors / chemistry
Protease Inhibitors / pharmacology
Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

Hydroxamic Acids
Lactams
Lipopolysaccharides
Matrix Metalloproteinase Inhibitors
Protease Inhibitors
SC 903
SE 205
Tumor Necrosis Factor-alpha
Metalloendopeptidases
Matrix Metalloproteinase 9
Matrix Metalloproteinase 1