4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2

J Med Chem. 2000 Mar 9;43(5):775-7. doi: 10.1021/jm990577v.
No abstract available

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Arthritis, Experimental / drug therapy
  • Cyclooxygenase 2
  • Edema / drug therapy
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Isoenzymes / blood
  • Isoenzymes / pharmacology*
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / pharmacology
  • Membrane Proteins
  • Prostaglandin-Endoperoxide Synthases / blood
  • Prostaglandin-Endoperoxide Synthases / pharmacology*
  • Rats
  • Recombinant Proteins / antagonists & inhibitors
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Enzyme Inhibitors
  • Isoenzymes
  • Isoxazoles
  • Membrane Proteins
  • Recombinant Proteins
  • Sulfonamides
  • valdecoxib
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases