Abstract
Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC(50)=2.99 and 1.80 microM) in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Calophyllum / chemistry*
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Cyclooxygenase 2 Inhibitors / chemistry
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Cyclooxygenase 2 Inhibitors / isolation & purification*
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Cyclooxygenase 2 Inhibitors / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Inhibitory Concentration 50
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Molecular Structure
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Plants, Medicinal / chemistry*
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Xanthones / chemistry
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Xanthones / isolation & purification*
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Xanthones / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase 2 Inhibitors
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Drugs, Chinese Herbal
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Xanthones