Abstract
The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells. However, inhibition of COX-2 pathway alone did not seem sufficient to inhibit cancer cell proliferation, and NO-release in a time-dependent manner strongly contributes to this activity.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation
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Chemistry, Pharmaceutical / methods*
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Cyclooxygenase 1 / metabolism
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Cyclooxygenase 2 / metabolism
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Cyclooxygenase Inhibitors / pharmacology
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Drug Design
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Humans
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Inhibitory Concentration 50
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Male
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Models, Chemical
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Nitric Oxide / chemistry*
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Prostatic Neoplasms / drug therapy*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Cyclooxygenase Inhibitors
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Nitric Oxide
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Cyclooxygenase 1
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Cyclooxygenase 2