Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity

J Nat Prod. 2010 Jul 23;73(7):1234-9. doi: 10.1021/np100057y.

Abstract

Seven new triterpene saponins, clematochinenosides A-G (1-7), together with 17 known saponins (8-24), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Compounds 1, 3-7, and 20-24 showed inhibitory activities against COX-1 and COX-2 enzymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Clematis / chemistry*
  • Cyclooxygenase 1 / drug effects
  • Cyclooxygenase 2 / drug effects
  • Cyclooxygenase 2 Inhibitors / chemistry
  • Cyclooxygenase 2 Inhibitors / isolation & purification*
  • Cyclooxygenase 2 Inhibitors / pharmacology*
  • Cyclooxygenase Inhibitors / chemistry
  • Cyclooxygenase Inhibitors / isolation & purification*
  • Cyclooxygenase Inhibitors / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Molecular Structure
  • Oleanolic Acid / analogs & derivatives
  • Oleanolic Acid / chemistry
  • Plant Roots / chemistry
  • Rhizome / chemistry
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Drugs, Chinese Herbal
  • Saponins
  • Triterpenes
  • Oleanolic Acid
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • hederagenin