Abstract
In pursuing our research on some 2,4-diamino-benzopyranopyrimidines and 2-amino-5,6-dihydrobenzo[h]quinazolines, previously reported as antiplatelet and analgesic/anti-inflammatory agents respectively, we designed and synthesized a new series of 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted. The insertion of amino substituents at positions 2 and 4 of the benzoquinazoline scaffold resulted in compounds endowed with a potent ASA-like antiplatelet activity, combined with an anti-inflammatory activity comparable, in some cases, to that of indomethacin, used as a reference drug.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
-
Analgesics / chemical synthesis
-
Analgesics / chemistry
-
Analgesics / pharmacology*
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Benzopyrans / chemical synthesis
-
Benzopyrans / chemistry
-
Benzopyrans / pharmacology*
-
Dose-Response Relationship, Drug
-
Drug Design
-
Edema / drug therapy*
-
Guinea Pigs
-
Mice
-
Models, Molecular
-
Molecular Structure
-
Platelet Aggregation / drug effects
-
Prostaglandin-Endoperoxide Synthases / metabolism
-
Pyrimidines / chemical synthesis
-
Pyrimidines / chemistry
-
Pyrimidines / pharmacology*
-
Quinazolines / chemical synthesis
-
Quinazolines / chemistry
-
Quinazolines / pharmacology*
-
Rats
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Analgesics
-
Anti-Inflammatory Agents, Non-Steroidal
-
Benzopyrans
-
Pyrimidines
-
Quinazolines
-
Prostaglandin-Endoperoxide Synthases