Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity

H Kawai; Y Kotake; S Ohta

doi:10.1016/s0960-894x(00)00326-7

Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity

Bioorg Med Chem Lett. 2000 Aug 7;10(15):1669-71. doi: 10.1016/s0960-894x(00)00326-7.

Authors

H Kawai¹, Y Kotake, S Ohta

Affiliation

¹ Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.

PMID: 10937721
DOI: 10.1016/s0960-894x(00)00326-7

Abstract

Endogenous amine 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) derivatives are synthesized. and their activity for dopaminergic systems are evaluated in vitro and in vivo by receptor binding assay and pharmacological tests. It is proposed that 1BnTIQ derivatives can act as endogenous dopaminergic antagonists.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry
Amines / pharmacology*
Animals
Corpus Striatum / metabolism*
Dopamine Antagonists / chemistry
Dopamine Antagonists / pharmacology*
Mice
Mice, Inbred C57BL
Motor Activity / drug effects*
Protein Binding
Receptors, Dopamine / metabolism*
Structure-Activity Relationship

Substances

Amines
Dopamine Antagonists
Receptors, Dopamine