Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships

J Med Chem. 1996 Aug 2;39(16):3179-87. doi: 10.1021/jm950721m.

Abstract

A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with dopaminergic activity is described. The structure-activity relationships of this series were studied by synthesis of analogs and evaluation of their affinities for the dopamine (DA) D2 receptor and inhibition of locomotor activity (LMA) in rodents. The basic amine, alkyne chain length, and aryl groups were varied. Compounds having a 4-phenyl-1,2,3,6-tetrahydropyridine and an aryl group with hydrogen-bonding substituents separated by a butynyl chain were found to have the most potent dopaminergic activity. Several compounds that were found to have exceptional in vivo activity in LMA inhibition in rodents were evaluated for additional pharmacological activity including binding affinities for other DA receptor subtypes as well as effects on brain DA synthesis, DA neuronal firing, and conditioned avoidance responding in squirrel monkeys.

MeSH terms

  • Alkynes / chemical synthesis*
  • Alkynes / pharmacology
  • Animals
  • Antipsychotic Agents / chemical synthesis*
  • Antipsychotic Agents / chemistry
  • Antipsychotic Agents / metabolism
  • Antipsychotic Agents / pharmacology
  • Binding, Competitive
  • Brain / drug effects
  • Dopamine / metabolism
  • Dopamine Agents / chemical synthesis*
  • Dopamine Agents / chemistry
  • Dopamine Agents / metabolism
  • Dopamine Agents / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Motor Activity / drug effects
  • Neurons / drug effects
  • Neurons / metabolism
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Pyridines / metabolism
  • Pyridines / pharmacology
  • Rats
  • Receptors, Dopamine D2 / metabolism*
  • Saimiri
  • Spiperone / metabolism
  • Structure-Activity Relationship

Substances

  • Alkynes
  • Antipsychotic Agents
  • Dopamine Agents
  • Pyridines
  • Receptors, Dopamine D2
  • Spiperone
  • Dopamine