Molecular cloning and characterization of a new receptor for galanin

FEBS Lett. 1997 Apr 1;405(3):285-90. doi: 10.1016/s0014-5793(97)00196-8.

Abstract

Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding, Competitive
  • Cloning, Molecular
  • Gene Expression
  • Molecular Sequence Data
  • Multigene Family
  • Rats
  • Receptors, Galanin
  • Receptors, Gastrointestinal Hormone / drug effects
  • Receptors, Gastrointestinal Hormone / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Tissue Distribution

Substances

  • Receptors, Galanin
  • Receptors, Gastrointestinal Hormone