Abstract
Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.
MeSH terms
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Animals
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Benzamides / chemical synthesis*
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Benzamides / chemistry
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Benzamides / pharmacology
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CHO Cells
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Cricetinae
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Cricetulus
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Humans
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Hypothalamic Hormones / metabolism*
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Ligands
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Melanins / metabolism*
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Pituitary Hormones / metabolism*
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Radioligand Assay
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Receptors, Pituitary Hormone / antagonists & inhibitors*
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Receptors, Pituitary Hormone / metabolism
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Structure-Activity Relationship
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Urea / analogs & derivatives*
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Urea / chemical synthesis*
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Urea / chemistry
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Urea / pharmacology
Substances
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Benzamides
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Hypothalamic Hormones
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Ligands
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Melanins
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Pituitary Hormones
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Receptors, Pituitary Hormone
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melanin-concentrating hormone
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Urea