4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5075-80. doi: 10.1016/j.bmcl.2004.07.077.

Abstract

Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzamides / chemical synthesis*
  • Benzamides / chemistry
  • Benzamides / pharmacology
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Humans
  • Hypothalamic Hormones / metabolism*
  • Ligands
  • Melanins / metabolism*
  • Pituitary Hormones / metabolism*
  • Radioligand Assay
  • Receptors, Pituitary Hormone / antagonists & inhibitors*
  • Receptors, Pituitary Hormone / metabolism
  • Structure-Activity Relationship
  • Urea / analogs & derivatives*
  • Urea / chemical synthesis*
  • Urea / chemistry
  • Urea / pharmacology

Substances

  • Benzamides
  • Hypothalamic Hormones
  • Ligands
  • Melanins
  • Pituitary Hormones
  • Receptors, Pituitary Hormone
  • melanin-concentrating hormone
  • Urea