Abstract
Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Glycoside Hydrolase Inhibitors*
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Molecular Structure
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Piperidines / chemical synthesis*
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Piperidines / chemistry
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Piperidines / pharmacology*
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beta-Glucosidase / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Piperidines
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beta-Glucosidase