Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of β-glucocerebrosidase

Chembiochem. 2011 Sep 19;12(14):2151-4. doi: 10.1002/cbic.201100332. Epub 2011 Jul 12.
No abstract available

MeSH terms

  • Alkylation
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Fibroblasts / drug effects*
  • Fibroblasts / enzymology*
  • Glucosylceramidase / antagonists & inhibitors*
  • Humans
  • Imino Pyranoses / chemical synthesis*
  • Imino Pyranoses / chemistry
  • Imino Pyranoses / pharmacology*
  • Kinetics

Substances

  • Enzyme Inhibitors
  • Imino Pyranoses
  • isofagomine
  • Glucosylceramidase