5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity

J Med Chem. 1994 Aug 5;37(16):2509-12. doi: 10.1021/jm00042a003.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Indoles / chemical synthesis*
  • Indoles / metabolism
  • Indoles / pharmacology
  • Molecular Conformation
  • Molecular Structure
  • Receptors, Serotonin / drug effects*
  • Serotonin Receptor Agonists / chemical synthesis*
  • Serotonin Receptor Agonists / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Sumatriptan / metabolism
  • Sumatriptan / pharmacology

Substances

  • Indoles
  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • CP 124439
  • Sumatriptan