Abstract
Chemical investigation of the aerial parts of Cimicifuga simplex afforded four new fukinolic acid analogues, cimicifugic acids K-N (1-4), and 10 known compounds, and C. japonica afforded three new fukinolic acid analogues, cimicifugic acids K-M (1-3), a new phenolic glycoside, shomaside F (5), and 10 known compounds. Cimicifugic acids K-N showed more potent hyaluronidase inhibitory activities than rosmarinic acid.
MeSH terms
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Caffeic Acids / chemistry
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Caffeic Acids / isolation & purification*
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Cimicifuga / chemistry*
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Cinnamates / pharmacology
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Depsides / pharmacology
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Hyaluronoglucosaminidase / antagonists & inhibitors*
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Japan
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Molecular Structure
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenylacetates / chemistry
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Phenylacetates / isolation & purification*
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Plants, Medicinal / chemistry*
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Rosmarinic Acid
Substances
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Caffeic Acids
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Cinnamates
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Depsides
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Phenols
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Phenylacetates
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cimicifugic acid
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Hyaluronoglucosaminidase
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fukinolic acid