Abstract
Recently, a new class of selective integrin alpha5beta1inhibitors consisting of a heterocyclic based scaffold was published. Herein the SAR and pharmacokinetic profiles of N-phenyl piperidine derivatives are described.
Copyright 2009 Elsevier Ltd. All rights reserved.
MeSH terms
-
Administration, Oral
-
Aminopyridines / chemical synthesis
-
Aminopyridines / chemistry*
-
Aminopyridines / pharmacokinetics
-
Animals
-
Dogs
-
Drug Design
-
Integrin alpha5beta1 / antagonists & inhibitors*
-
Integrin alpha5beta1 / metabolism
-
Male
-
Phenylalanine / analogs & derivatives*
-
Phenylalanine / chemical synthesis
-
Phenylalanine / chemistry
-
Phenylalanine / pharmacokinetics
-
Piperidines / chemical synthesis
-
Piperidines / chemistry*
-
Piperidines / pharmacokinetics
-
Rats
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Aminopyridines
-
Integrin alpha5beta1
-
Piperidines
-
Phenylalanine