Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation

Vincent Rerat; Sophie Laurent; Carmen Burtéa; Benoît Driesschaert; Vincent Pourcelle; Luce Vander Elst; Robert N Muller; Jacqueline Marchand-Brynaert

doi:10.1016/j.bmcl.2010.01.150

Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1861-5. doi: 10.1016/j.bmcl.2010.01.150. Epub 2010 Feb 4.

Authors

Vincent Rerat¹, Sophie Laurent, Carmen Burtéa, Benoît Driesschaert, Vincent Pourcelle, Luce Vander Elst, Robert N Muller, Jacqueline Marchand-Brynaert

Affiliation

¹ Unité de Chimie Organique et Médicinale, Université Catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.

PMID: 20172716
DOI: 10.1016/j.bmcl.2010.01.150

Abstract

Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ferric Compounds / chemistry*
Molecular Mimicry*
Oligopeptides / chemistry*
Particle Size
Spectrum Analysis / methods
X-Rays

Substances

Ferric Compounds
Oligopeptides
ferric oxide
arginyl-glycyl-aspartic acid