A solid-phase synthesis for beta-turn mimetics of sialyl Lewis X

K Kurokawa; H Kumihara; H Kondo

doi:10.1016/s0960-894x(00)00358-9

A solid-phase synthesis for beta-turn mimetics of sialyl Lewis X

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1827-30. doi: 10.1016/s0960-894x(00)00358-9.

Authors

K Kurokawa¹, H Kumihara, H Kondo

Affiliation

¹ Department of Chemistry, R&D Laboratories, Nippon Organon K.K., Osaka, Japan.

PMID: 10969978
DOI: 10.1016/s0960-894x(00)00358-9

Abstract

A solid-phase synthesis of heterocyclic beta-turn mimetics of sialyl Lewis X, which is a natural carbohydrate ligand of selectins, was established. This synthetic method could be very useful for drug discovery of selectin antagonists using combinatorial chemistry techniques.

MeSH terms

Enzyme-Linked Immunosorbent Assay
Heterocyclic Compounds, 1-Ring / chemical synthesis*
Heterocyclic Compounds, 1-Ring / chemistry
Heterocyclic Compounds, 1-Ring / metabolism
Heterocyclic Compounds, 1-Ring / pharmacology*
Mannosides / chemical synthesis*
Mannosides / chemistry
Mannosides / metabolism
Mannosides / pharmacology*
Molecular Mimicry
Molecular Structure
Oligosaccharides / chemistry*
Oligosaccharides / metabolism
Protein Structure, Secondary
Selectins / chemistry*
Selectins / metabolism*
Sialyl Lewis X Antigen

Substances

Heterocyclic Compounds, 1-Ring
Mannosides
Oligosaccharides
Selectins
Sialyl Lewis X Antigen