Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists

J Med Chem. 1993 Nov 26;36(24):3982-4. doi: 10.1021/jm00076a030.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bronchoconstriction / drug effects
  • Cell Membrane / metabolism
  • Guinea Pigs
  • Humans
  • Leukotriene B4 / pharmacology
  • Lung / metabolism
  • Molecular Structure
  • Neutrophils / metabolism
  • Phenols / chemical synthesis
  • Phenols / metabolism
  • Phenols / pharmacology*
  • Receptors, Leukotriene B4 / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Xanthenes / chemical synthesis
  • Xanthenes / metabolism
  • Xanthenes / pharmacology*

Substances

  • Phenols
  • Receptors, Leukotriene B4
  • Xanthenes
  • LY 292728
  • Leukotriene B4