Abstract
A prefractionated Streptomyces-derived extract was initially identified as being active using a luciferase-based AMP-activated protein kinase (AMPK) assay. Bioassay-guided fractionation led to the isolation of the new compound quinazolin-4(3H)-one (1) as the active component. However, 1 was shown to have potent firefly luciferase inhibitory activity with no effect on AMPK. This is the first report of a natural luciferase inhibitor.
MeSH terms
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AMP-Activated Protein Kinases / metabolism*
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Animals
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Biological Products / chemistry
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Biological Products / isolation & purification*
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Biological Products / pharmacology*
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Luciferases, Firefly / antagonists & inhibitors*
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Luciferases, Firefly / metabolism
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Molecular Structure
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Quinazolinones / chemistry
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Quinazolinones / isolation & purification*
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Quinazolinones / pharmacology*
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Streptomyces / chemistry*
Substances
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2-(4'-(methylamino)phenyl)quinazolin-4(3H)-one
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Biological Products
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Quinazolinones
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Luciferases, Firefly
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AMP-Activated Protein Kinases