Carboxyalkyl dipeptides with atrial natriuretic factor potentiating and antihypertensive activity

J Med Chem. 1989 Apr;32(4):737-9. doi: 10.1021/jm00124a002.
No abstract available

MeSH terms

  • Alkylation
  • Animals
  • Atrial Natriuretic Factor / blood
  • Atrial Natriuretic Factor / pharmacology*
  • Atrial Natriuretic Factor / therapeutic use
  • Blood Pressure / drug effects
  • Chemical Phenomena
  • Chemistry
  • Dipeptides / chemical synthesis
  • Dipeptides / pharmacology*
  • Dipeptides / therapeutic use
  • Drug Synergism
  • Half-Life
  • Hypertension / drug therapy*
  • Kidney / enzymology
  • Neprilysin / antagonists & inhibitors*
  • Neprilysin / metabolism
  • Rabbits
  • Rats

Substances

  • Dipeptides
  • Atrial Natriuretic Factor
  • Neprilysin