Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge

Antimicrob Agents Chemother. 2009 Oct;53(10):4051-63. doi: 10.1128/AAC.00084-09. Epub 2009 May 26.

Authors

Leticia I Llarrull¹, Jed F Fisher, Shahriar Mobashery

Affiliation

¹ Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / pharmacology*
Cell Wall / drug effects
Cell Wall / metabolism
Methicillin Resistance / genetics
Methicillin Resistance / physiology*
Methicillin-Resistant Staphylococcus aureus / drug effects
Methicillin-Resistant Staphylococcus aureus / metabolism
Penicillin-Binding Proteins / chemistry
Penicillin-Binding Proteins / metabolism
Penicillin-Binding Proteins / physiology
Peptide Synthases / chemistry
Peptide Synthases / metabolism
Peptide Synthases / physiology
Staphylococcus aureus / drug effects*
Staphylococcus aureus / metabolism*
beta-Lactams / pharmacology*

Substances

Anti-Bacterial Agents
Penicillin-Binding Proteins
beta-Lactams
penicillin-binding protein 2a, Streptococcus
Peptide Synthases