Abstract
Capuramycin analogues with a variety of substituents in place of the azepan-2-one moiety were synthesized from A-500359E and were tested for their translocase I inhibitory activity and in vitro antimycobacterial activity. Phenyl-type moieties were found to be effective substituents for capuramycin analogues.
MeSH terms
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Aminoglycosides / chemical synthesis*
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Aminoglycosides / chemistry
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Aminoglycosides / pharmacology*
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Azepines / chemistry*
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Azepines / pharmacology*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Mycobacterium / drug effects
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Structure-Activity Relationship
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Transferases / antagonists & inhibitors
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Azepines
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Enzyme Inhibitors
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capuramycin
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Transferases