Sesquiterpenoids and plasmin-inhibitory flavonoids from Blumea balsamifera

J Nat Prod. 2005 Mar;68(3):447-9. doi: 10.1021/np049622e.

Abstract

Two new sesquiterpenoid esters (1 and 2) were isolated from the extract of Blumea balsamifera, a tropical Compositae plant. Compound 2 proved to be weakly cytotoxic when tested against Jurkat human T-cell leukemia cells. Nine known flavonoids, of which two showed plasmin-inhibitory activity, were also isolated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Asteraceae / chemistry*
  • Drug Screening Assays, Antitumor
  • Fibrinolysin / antagonists & inhibitors*
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Jurkat Cells / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Thailand

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavonoids
  • Sesquiterpenes
  • Fibrinolysin