Investigations of azapeptides as mimetics of Leu-enkephalin

H Han; J Yoon; K D Janda

doi:10.1016/s0960-894x(97)10198-6

Investigations of azapeptides as mimetics of Leu-enkephalin

Bioorg Med Chem Lett. 1998 Jan 6;8(1):117-20. doi: 10.1016/s0960-894x(97)10198-6.

Authors

H Han¹, J Yoon, K D Janda

Affiliation

¹ Department of Chemistry, Scripps Research Institute, La Jolla, CA, USA.

PMID: 9871637
DOI: 10.1016/s0960-894x(97)10198-6

Abstract

Solution syntheses of azapeptide pentamers 2, 3, and 4 were accomplished. The binding affinity of these azapeptides and azatide 1 were examined in the context of monoclonal antibody 3-E7 known to strongly bind the [Leu5]enkephalin sequence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enkephalin, Leucine / chemistry*
Enkephalin, Leucine / immunology
Enzyme-Linked Immunosorbent Assay
Molecular Mimicry*
Oligopeptides / chemical synthesis*
Oligopeptides / chemistry
Oligopeptides / immunology
Protein Binding

Substances

Oligopeptides
Enkephalin, Leucine