Development of potent and selective factor Xa inhibitors

Bioorg Med Chem Lett. 2001 Jul 23;11(14):1797-800. doi: 10.1016/s0960-894x(01)00311-0.

Abstract

The development of potent and selective small molecule inhibitors of factor Xa is described.

MeSH terms

  • Amidines / chemistry
  • Amidines / pharmacology*
  • Antithrombin III / chemical synthesis*
  • Antithrombin III / pharmacology*
  • Crystallography
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fibrinolysin / drug effects
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Structure-Activity Relationship
  • Thrombin / drug effects*
  • Trypsin / drug effects
  • Urokinase-Type Plasminogen Activator / drug effects*

Substances

  • 2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine
  • Amidines
  • Enzyme Inhibitors
  • Indoles
  • Antithrombin III
  • Trypsin
  • Thrombin
  • Fibrinolysin
  • Urokinase-Type Plasminogen Activator