Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella

Y Nakao; N Oku; S Matsunaga; N Fusetani

doi:10.1021/np970544n

Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella

J Nat Prod. 1998 May;61(5):667-70. doi: 10.1021/np970544n.

Authors

Y Nakao¹, N Oku, S Matsunaga, N Fusetani

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 9599274
DOI: 10.1021/np970544n

Abstract

Two new potent serine protease inhibitors, cyclotheonamides E2 (3) and E3 (4), have been isolated from a marine sponge of the genus Theonella. Their structures were determined by interpretation of spectral data and chemical degradation studies. They are closely related to the previously reported cyclotheonamide E, from which they differ in the N-acyl group of the alanyl side chain. Cyclotheonamides E, E2, and E3 were more active against thrombin than against trypsin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Porifera / chemistry*
Serine Proteinase Inhibitors / isolation & purification*
Serine Proteinase Inhibitors / pharmacology
Thrombin / antagonists & inhibitors*
Trypsin Inhibitors / isolation & purification*
Trypsin Inhibitors / pharmacology

Substances

Peptides, Cyclic
Serine Proteinase Inhibitors
Trypsin Inhibitors
cyclotheonamide E2
cyclotheonamide E3
Thrombin