Abstract
RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg.
MeSH terms
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Mice
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Mice, Nude
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Neoplasms, Experimental / blood supply*
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Neovascularization, Pathologic*
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Pyrimidines / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Fibroblast Growth Factor / antagonists & inhibitors
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Receptors, Platelet-Derived Growth Factor / antagonists & inhibitors
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Vascular Endothelial Growth Factor A / physiology
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Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
Substances
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Angiogenesis Inhibitors
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Pyrimidines
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RO4396686
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Receptors, Fibroblast Growth Factor
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Vascular Endothelial Growth Factor A
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Receptors, Platelet-Derived Growth Factor
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Vascular Endothelial Growth Factor Receptor-2