The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

Bioorg Med Chem. 2013 Jul 15;21(14):4378-87. doi: 10.1016/j.bmc.2013.04.075. Epub 2013 May 6.

Abstract

An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Molecular Structure
  • Neurotensin / antagonists & inhibitors*
  • Prostatic Neoplasms / drug therapy
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry

Substances

  • Pyrazoles
  • Quinolines
  • SR 48692
  • Neurotensin