Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

M Caldarelli; J Habermann; S V Ley

doi:10.1016/s0960-894x(99)00311-x

Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

Bioorg Med Chem Lett. 1999 Jul 19;9(14):2049-52. doi: 10.1016/s0960-894x(99)00311-x.

Authors

M Caldarelli¹, J Habermann, S V Ley

Affiliation

¹ Department of Chemistry, University of Cambridge, United Kingdom.

PMID: 10450979
DOI: 10.1016/s0960-894x(99)00311-x

Abstract

Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Organic / methods*
Chromatography, Liquid / methods
Hydroxamic Acids / chemistry
Indicators and Reagents / chemistry
Magnetic Resonance Spectroscopy
Mass Spectrometry / methods
Matrix Metalloproteinase Inhibitors
Metalloendopeptidases / antagonists & inhibitors*
Polymers / chemistry
Protease Inhibitors / chemical synthesis*
Pyrazines*
Sulfonamides

Substances

CGS 27023A
Hydroxamic Acids
Indicators and Reagents
Matrix Metalloproteinase Inhibitors
Polymers
Protease Inhibitors
Pyrazines
Sulfonamides
Metalloendopeptidases