Abstract
Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1a-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Biphenyl Compounds / chemical synthesis*
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Biphenyl Compounds / pharmacology*
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Chromatography, Thin Layer
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Indicators and Reagents
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Isotope Labeling
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Matrix Metalloproteinase 13
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Matrix Metalloproteinase Inhibitors*
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Molecular Conformation
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Neoplasms / diagnostic imaging*
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Protease Inhibitors / chemical synthesis*
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Radiopharmaceuticals / chemical synthesis*
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Sulfonamides / chemical synthesis*
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Sulfonamides / pharmacology*
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Tomography, Emission-Computed
Substances
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Biphenyl Compounds
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Indicators and Reagents
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Matrix Metalloproteinase Inhibitors
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Protease Inhibitors
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Radiopharmaceuticals
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Sulfonamides
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Matrix Metalloproteinase 13