Discovery of potent, achiral matrix metalloproteinase inhibitors

J Med Chem. 1998 Sep 10;41(19):3568-71. doi: 10.1021/jm980253r.
No abstract available

MeSH terms

  • Crystallography, X-Ray
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 3 / metabolism
  • Matrix Metalloproteinase 7
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase Inhibitors
  • Metalloendopeptidases / antagonists & inhibitors*
  • Metalloendopeptidases / metabolism
  • Models, Molecular
  • Molecular Conformation
  • Piperazines / chemical synthesis*
  • Piperazines / chemistry
  • Piperazines / metabolism
  • Piperazines / pharmacology
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / metabolism
  • Protease Inhibitors / pharmacology
  • Protein Binding
  • Structure-Activity Relationship

Substances

  • Matrix Metalloproteinase Inhibitors
  • Piperazines
  • Protease Inhibitors
  • Metalloendopeptidases
  • Matrix Metalloproteinase 3
  • Matrix Metalloproteinase 7
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 1