Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties

J Med Chem. 1996 Nov 8;39(23):4531-6. doi: 10.1021/jm960572n.
No abstract available

MeSH terms

  • Animals
  • Antithrombins / chemical synthesis*
  • Antithrombins / chemistry
  • Antithrombins / pharmacokinetics
  • Arginine / chemistry*
  • Biological Availability
  • Dogs
  • Drug Design
  • Lactams / chemistry*
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Antithrombins
  • Lactams
  • Arginine