Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity

Chia-Ying Li; Tian-Shung Wu

doi:10.1021/np020188v

Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity

J Nat Prod. 2002 Oct;65(10):1452-6. doi: 10.1021/np020188v.

Authors

Chia-Ying Li¹, Tian-Shung Wu

Affiliation

¹ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, Republic of China.

PMID: 12398542
DOI: 10.1021/np020188v

Abstract

Four new compounds, crocusatins F (1), G (2), H (3), and I (4a), together with 21 known compounds, were isolated from an aqueous extract of the stigmas of Crocus sativus (saffron). The structures of 1-4 were established by spectral methods. The tyrosinase inhibitory activities of all 25 compounds isolated were evaluated in vitro using mushroom tyrosinase. Among them, crocusatin H (3), crocin-1 (5), and crocin-3 (6) showed significant tyrosinase inhibitory activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crocus / chemistry*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Monophenol Monooxygenase / antagonists & inhibitors*
Spectrum Analysis

Substances

Enzyme Inhibitors
Monophenol Monooxygenase