Abstract
Three new ent-kaurane type diterpenes, broussonetones A-C (1-3), were isolated from leaves of Broussonetia papyrifera, together with seven known compounds, and their structures determined by 1D and 2D NMR and MS methods. Compounds 1-3 were marginal inhibitors of tyrosinase. Antioxidant assays showed them also to be inhibitors of xanthine oxidase. The mild inhibition of tyrosinase and significant inhibition of xanthine oxidase suggests that 1-3 could be useful ingredients in the development of skin-protecting cosmetics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology*
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Biphenyl Compounds / pharmacology
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Broussonetia / chemistry*
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology*
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Drug Screening Assays, Antitumor
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Molecular Structure
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Monophenol Monooxygenase / antagonists & inhibitors*
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Picrates / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Taiwan
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Xanthine Oxidase / antagonists & inhibitors
Substances
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Biphenyl Compounds
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Diterpenes, Kaurane
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Picrates
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broussonetone A
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broussonetone B
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broussonetone C
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1,1-diphenyl-2-picrylhydrazyl
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Monophenol Monooxygenase
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Xanthine Oxidase