Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyrifera

J Nat Prod. 2008 Nov;71(11):1930-3. doi: 10.1021/np800564z. Epub 2008 Nov 6.

Abstract

Three new ent-kaurane type diterpenes, broussonetones A-C (1-3), were isolated from leaves of Broussonetia papyrifera, together with seven known compounds, and their structures determined by 1D and 2D NMR and MS methods. Compounds 1-3 were marginal inhibitors of tyrosinase. Antioxidant assays showed them also to be inhibitors of xanthine oxidase. The mild inhibition of tyrosinase and significant inhibition of xanthine oxidase suggests that 1-3 could be useful ingredients in the development of skin-protecting cosmetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology*
  • Biphenyl Compounds / pharmacology
  • Broussonetia / chemistry*
  • Diterpenes, Kaurane / chemistry
  • Diterpenes, Kaurane / isolation & purification*
  • Diterpenes, Kaurane / pharmacology*
  • Drug Screening Assays, Antitumor
  • Molecular Structure
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Picrates / pharmacology
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Taiwan
  • Xanthine Oxidase / antagonists & inhibitors

Substances

  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Biphenyl Compounds
  • Diterpenes, Kaurane
  • Picrates
  • broussonetone A
  • broussonetone B
  • broussonetone C
  • 1,1-diphenyl-2-picrylhydrazyl
  • Monophenol Monooxygenase
  • Xanthine Oxidase