PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase

Bioorg Med Chem Lett. 2009 Jan 1;19(1):36-9. doi: 10.1016/j.bmcl.2008.11.020. Epub 2008 Nov 13.

Abstract

In this work, the PEG-immobilization and the liquid phase synthesis of some coumarins derived from cardol are presented. Some preliminary results on their tyrosinase inhibitory activity are also included.

MeSH terms

  • Agaricales / enzymology*
  • Coumarins / chemical synthesis*
  • Coumarins / pharmacology*
  • Fungal Proteins
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Polyethylene Glycols*
  • Polymers*
  • Resorcinols / chemistry*
  • Solubility

Substances

  • Coumarins
  • Fungal Proteins
  • Polymers
  • Resorcinols
  • Polyethylene Glycols
  • coumarin
  • Monophenol Monooxygenase
  • adipostatin A