2. Membrane Transporter/Ion Channel
  3. Apical Sodium-Dependent Bile Acid Transporter
  4. SC-435

SC-435 is an apical sodium-dependent Bile acid (BA) transporter inhibitor. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations.

For research use only. We do not sell to patients.

SC-435 Chemical Structure

SC-435 Chemical Structure

CAS No. : 289037-67-8

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5 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SC-435 is an apical sodium-dependent Bile acid (BA) transporter inhibitor. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations[1].

IC50 & Target

Bile acid transporter[1]
Molecular Weight

722.01

Formula

C37H59N3O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)([O-])=O.O[C@@H]1[C@@](C2=CC=C(C=C2)OCCCC[N+]34CCN(CC4)CC3)([H])C5=CC(N(C)C)=CC=C5S(=O)(CC1(CCCC)CCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (69.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3850 mL 6.9251 mL 13.8502 mL
5 mM 0.2770 mL 1.3850 mL 2.7700 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3850 mL 6.9251 mL 13.8502 mL 34.6256 mL
5 mM 0.2770 mL 1.3850 mL 2.7700 mL 6.9251 mL
10 mM 0.1385 mL 0.6925 mL 1.3850 mL 3.4626 mL
15 mM 0.0923 mL 0.4617 mL 0.9233 mL 2.3084 mL
20 mM 0.0693 mL 0.3463 mL 0.6925 mL 1.7313 mL
25 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3850 mL
30 mM 0.0462 mL 0.2308 mL 0.4617 mL 1.1542 mL
40 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8656 mL
50 mM 0.0277 mL 0.1385 mL 0.2770 mL 0.6925 mL
60 mM 0.0231 mL 0.1154 mL 0.2308 mL 0.5771 mL
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SC-435 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC-435289037-67-8SC435SC 435Apical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2Bile acidBAcholesterolInhibitorinhibitorinhibit

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