2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Pentabromopseudilin

Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer.

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Pentabromopseudilin Chemical Structure

Pentabromopseudilin Chemical Structure

CAS No. : 10245-81-5

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Pentabromopseudilin Related Antibodies

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Description

Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].
In Vitro

Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) prevents TGF-β-induced Smad protein phosphorylation and nuclear translocation[1].
PBrP (0.5 μM, 6 h) inhibits TGF-β-stimulated transcriptional responses[1].
PBrP (0-1 μM, 6 h) inhibits TGF-β-induced EMT in A549 cells[1].
PBrP (0.2 μM, 20 h) suppresses TGF-β-induced cell migration[1].
PBrP (0.01-1 μM, 6 h) blocks TGF-β signalling by enhancing degradation of TβRII[1].
PBrP (0.5 μM, 0, 1, 3 h) blocks TGF-β signalling by enhancing degradation of TβRII via caveolae[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentabromopseudilin Related Antibodies

Western Blot Analysis[1]

Cell Line: Mv1Lu, A549, Clone 9 and HepG2 cells
Concentration: 0.01-1 μM (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5 μM (Mv1Lu, A549 and HepG2 cells)
Incubation Time: 6 h (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5, 1, 2, 4, 6 h (Mv1Lu, A549 and HepG2 cells)
Result: Suppressed the TGF-β-stimulated Smad2/3 phosphorylation in a dose-dependent manner in these cell lines.
Prevented TGF-β induced the nuclear translocation of Smad2/3 and PBrP alone did not alter the localisation of Smad proteins.

Immunofluorescence[1]

Cell Line: A549 cells
Concentration: 0.2 μM
Incubation Time: 6 h
Result: Abolished TGF-β-induced Smad2/3 nuclear translocation.

Cell Migration Assay [1]

Cell Line: A549 cells
Concentration: 0.2 μM
Incubation Time: 20 h
Result: Suppressed TGF-β-stimulated cell migration and did not close the wound.
Molecular Weight

553.66

Formula

C10H4Br5NO
CAS No.
SMILES

OC1=C(C2=C(Br)C(Br)=C(Br)N2)C=C(Br)C=C1Br
Structure Classification
Initial Source

Pseudomonas bromoutilis
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pentabromopseudilin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentabromopseudilin10245-81-5TGF-β ReceptorTransforming growth factor beta receptorsantibioticPseudomonas bromoutilisAlteromonas luteoviolaceusantimicrobialanti-tumourphytotoxicMyoVaTGF-βfibrotic diseasescancerInhibitorinhibitorinhibit

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