2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. ALOX15-IN-2

ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively.

For research use only. We do not sell to patients.

ALOX15-IN-2 Chemical Structure

ALOX15-IN-2 Chemical Structure

CAS No. : 2764818-23-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 210 In-stock
25 mg USD 420 In-stock
50 mg USD 720 In-stock
100 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

ALOX15-IN-2 Related Antibodies

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Description

ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].

Molecular Weight

443.56

Formula

C23H29N3O4S
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=S(NC1=CC=CC(C2=CC3=C(C=CC=C3)N2)=C1)(NC(OCCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (225.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2545 mL 11.2724 mL 22.5449 mL
5 mM 0.4509 mL 2.2545 mL 4.5090 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

COA (243 KB) HNMR (120 KB) RP-HPLC (169 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2545 mL 11.2724 mL 22.5449 mL 56.3622 mL
5 mM 0.4509 mL 2.2545 mL 4.5090 mL 11.2724 mL
10 mM 0.2254 mL 1.1272 mL 2.2545 mL 5.6362 mL
15 mM 0.1503 mL 0.7515 mL 1.5030 mL 3.7575 mL
20 mM 0.1127 mL 0.5636 mL 1.1272 mL 2.8181 mL
25 mM 0.0902 mL 0.4509 mL 0.9018 mL 2.2545 mL
30 mM 0.0751 mL 0.3757 mL 0.7515 mL 1.8787 mL
40 mM 0.0564 mL 0.2818 mL 0.5636 mL 1.4091 mL
50 mM 0.0451 mL 0.2254 mL 0.4509 mL 1.1272 mL
60 mM 0.0376 mL 0.1879 mL 0.3757 mL 0.9394 mL
80 mM 0.0282 mL 0.1409 mL 0.2818 mL 0.7045 mL
100 mM 0.0225 mL 0.1127 mL 0.2254 mL 0.5636 mL
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ALOX15-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALOX15-IN-22764818-23-5LipoxygenaseLOXALOX15 orthologslinoleic acidarachidonic acidInhibitorinhibitorinhibit

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