2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Cathepsin K inhibitor 3

Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies.

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Cathepsin K inhibitor 3 Chemical Structure

Cathepsin K inhibitor 3 Chemical Structure

CAS No. : 1694638-70-4

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Cathepsin K inhibitor 3 Related Antibodies

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Description

Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].

IC50 & Target[1]

cathepsin K

0.5 nM (IC50)

In Vivo

Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1].
The pharmacokinetic parameters of compound 23

Parameters Cl(mL/min/kg) T1/2(h) %F
Rat 13 1 33
Dog 3.1 4.1 38
Rhesus 18.5 2.3 55

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

562.65

Formula

C30H31FN4O4S
CAS No.
SMILES

O=S1(CCN(CC1)C2=CC=C(C3=C([C@@H]4CCCC[C@H]4C(NC5(CC5)C#N)=O)OC(C6=CC=C(C=C6)F)=N3)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cathepsin K inhibitor 3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathepsin K inhibitor 31694638-70-4Cathepsin K inhibitor3Cathepsin K inhibitor-3CathepsinCathepsin KosteoarthritisInhibitorinhibitorinhibit

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Cathepsin K inhibitor 3
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