2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. MLS-0437605

MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs).

For research use only. We do not sell to patients.

MLS-0437605 Chemical Structure

MLS-0437605 Chemical Structure

CAS No. : 862975-18-6

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

MLS-0437605 Related Antibodies

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Description

MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs)[1].

In Vitro

MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLS-0437605 Related Antibodies
Molecular Weight

342.35

Formula

C16H11FN4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C2=NN=C(NC3=NC4=C(F)C=CC=C4S3)O2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20.83 mg/mL (60.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9210 mL 14.6049 mL 29.2099 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.92%

COA (249 KB) HNMR (273 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9210 mL 14.6049 mL 29.2099 mL 73.0247 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL 14.6049 mL
10 mM 0.2921 mL 1.4605 mL 2.9210 mL 7.3025 mL
15 mM 0.1947 mL 0.9737 mL 1.9473 mL 4.8683 mL
20 mM 0.1460 mL 0.7302 mL 1.4605 mL 3.6512 mL
25 mM 0.1168 mL 0.5842 mL 1.1684 mL 2.9210 mL
30 mM 0.0974 mL 0.4868 mL 0.9737 mL 2.4342 mL
40 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8256 mL
50 mM 0.0584 mL 0.2921 mL 0.5842 mL 1.4605 mL
60 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2171 mL
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MLS-0437605 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLS-0437605862975-18-6MLS0437605MLS 0437605PhosphataseDUSP3SykPLCγ2anti-thromboticPTPInhibitorinhibitorinhibit

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