Compile Data Set for Download or QSAR

Found 238 hits with Last Name = 'abel' and Initial = 'u'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50231755 (6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...) Show SMILES CC1(C)CCc2nc(ccc2C1=O)C#Cc1ccccc1 Show InChI InChI=1S/C19H17NO/c1-19(2)13-12-17-16(18(19)21)11-10-15(20-17)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443088 (CHEMBL3087216) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(Cl)c1 |r,TLB:2:4:9.10.12:6.7| Show InChI InChI=1S/C17H18ClNO3/c1-22-16(20)19-14-5-6-15(19)11-17(21,10-14)8-7-12-3-2-4-13(18)9-12/h2-4,9,14-15,21H,5-6,10-11H2,1H3/t14-,15+,17+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438277 (CHEMBL2408412) Show SMILES CC1CC(=O)c2cc(cnc2C1)C#Cc1ccccc1 Show InChI InChI=1S/C18H15NO/c1-13-9-17-16(18(20)10-13)11-15(12-19-17)8-7-14-5-3-2-4-6-14/h2-6,11-13H,9-10H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443089 (CHEMBL3086715) Show SMILES COC(=O)N1CCC(O)(C#Cc2cccc(C)c2)[C@@H]2CCC[C@H]12 |r| Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)9-10-19(22)11-12-20(18(21)23-2)17-8-4-7-16(17)19/h3,5-6,13,16-17,22H,4,7-8,11-12H2,1-2H3/t16-,17+,19?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443089 (CHEMBL3086715) Show SMILES COC(=O)N1CCC(O)(C#Cc2cccc(C)c2)[C@@H]2CCC[C@H]12 |r| Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)9-10-19(22)11-12-20(18(21)23-2)17-8-4-7-16(17)19/h3,5-6,13,16-17,22H,4,7-8,11-12H2,1-2H3/t16-,17+,19?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28.4	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438295 (CHEMBL2408568) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1 Show InChI InChI=1S/C15H14ClN3O/c1-9-6-13-12(14(20)7-9)8-17-15(19-13)18-11-4-2-10(16)3-5-11/h2-5,8-9H,6-7H2,1H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443090 (CHEMBL3086712) Show SMILES COC(=O)N1CCC2CC(O)(C#Cc3cccc(C)c3)C2C1 Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)6-8-18(21)11-15-7-9-19(12-16(15)18)17(20)22-2/h3-5,10,15-16,21H,7,9,11-12H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438289 (CHEMBL2408574) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)nc3)nc2C1 Show InChI InChI=1S/C14H13ClN4O/c1-8-4-11-10(12(20)5-8)7-17-14(19-11)18-9-2-3-13(15)16-6-9/h2-3,6-8H,4-5H2,1H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443091 (CHEMBL3087511) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,THB:2:4:10.12.9:7.6| Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)8-9-18(21)11-15-6-7-16(12-18)19(15)17(20)22-2/h3-5,10,15-16,21H,6-7,11-12H2,1-2H3/t15-,16+,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443092 (CHEMBL3085792) Show SMILES CCOC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,TLB:3:5:10.11.13:7.8| Show InChI InChI=1S/C19H23NO3/c1-3-23-18(21)20-16-7-8-17(20)13-19(22,12-16)10-9-15-6-4-5-14(2)11-15/h4-6,11,16-17,22H,3,7-8,12-13H2,1-2H3/t16-,17+,19+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443093 (CHEMBL3087217) Show SMILES COC(=O)N1[C@@H]2CC[C@@H]1CC(O)(C2)C#Cc1cccc(C)c1 |r,TLB:2:4:6.7:12.10.9,13:10:4:6.7,THB:11:10:4:6.7| Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)8-9-18(21)11-15-6-7-16(12-18)19(15)17(20)22-2/h3-5,10,15-16,21H,6-7,11-12H2,1-2H3/t15-,16-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443087 (CHEMBL3087214) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(F)c1 |r,TLB:2:4:9.10.12:6.7| Show InChI InChI=1S/C17H18FNO3/c1-22-16(20)19-14-5-6-15(19)11-17(21,10-14)8-7-12-3-2-4-13(18)9-12/h2-4,9,14-15,21H,5-6,10-11H2,1H3/t14-,15+,17+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443086 (CHEMBL3087508) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)C#Cc1cccc(C)c1 |r,TLB:2:4:9.10.11:6.7| Show InChI InChI=1S/C18H21NO2/c1-13-4-3-5-14(10-13)6-7-15-11-16-8-9-17(12-15)19(16)18(20)21-2/h3-5,10,15-17H,8-9,11-12H2,1-2H3/t15-,16-,17+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438278 (CHEMBL2408411) Show SMILES CC1(C)CC(=O)c2cc(cnc2C1)C#Cc1ccccc1 Show InChI InChI=1S/C19H17NO/c1-19(2)11-17-16(18(21)12-19)10-15(13-20-17)9-8-14-6-4-3-5-7-14/h3-7,10,13H,11-12H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443085 (AFQ056 | Mavoglurant) Show SMILES COC(=O)N1CC[C@@H]2[C@H]1CCC[C@@]2(O)C#Cc1cccc(C)c1 |r| Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)8-11-19(22)10-4-7-17-16(19)9-12-20(17)18(21)23-2/h3,5-6,13,16-17,22H,4,7,9-10,12H2,1-2H3/t16-,17-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443084 (CHEMBL3087220) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(OC(F)F)c1 |r,TLB:2:4:9.10.12:6.7| Show InChI InChI=1S/C18H19F2NO4/c1-24-17(22)21-13-5-6-14(21)11-18(23,10-13)8-7-12-3-2-4-15(9-12)25-16(19)20/h2-4,9,13-14,16,23H,5-6,10-11H2,1H3/t13-,14+,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443083 (CHEMBL3087219) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(OC)c1 |r,TLB:2:4:9.10.12:6.7| Show InChI InChI=1S/C18H21NO4/c1-22-16-5-3-4-13(10-16)8-9-18(21)11-14-6-7-15(12-18)19(14)17(20)23-2/h3-5,10,14-15,21H,6-7,11-12H2,1-2H3/t14-,15+,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438294 (CHEMBL2408569) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(cc3)C#N)nc2C1 Show InChI InChI=1S/C16H14N4O/c1-10-6-14-13(15(21)7-10)9-18-16(20-14)19-12-4-2-11(8-17)3-5-12/h2-5,9-10H,6-7H2,1H3,(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443082 (CHEMBL3087513) Show SMILES COC(=O)N1C[C@@H]2CC[C@H]1C[C@@]2(O)C#Cc1cccc(C)c1 |r,TLB:2:4:11.10:7.8| Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)8-9-18(21)11-16-7-6-15(18)12-19(16)17(20)22-2/h3-5,10,15-16,21H,6-7,11-12H2,1-2H3/t15-,16-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438298 (CHEMBL2408565) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1 Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443081 (CHEMBL3087212) Show SMILES COC(=O)N1CCCCC11CCCC(O)(C1)C#Cc1cccc(C)c1 Show InChI InChI=1S/C21H27NO3/c1-17-7-5-8-18(15-17)9-13-21(24)12-6-11-20(16-21)10-3-4-14-22(20)19(23)25-2/h5,7-8,15,24H,3-4,6,10-12,14,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443080 (CHEMBL3087514) Show SMILES COC(=O)N1C[C@@H]2CCC(O)(C#Cc3cccc(C)c3)[C@@H]2C1 |r| Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)6-8-18(21)9-7-15-11-19(12-16(15)18)17(20)22-2/h3-5,10,15-16,21H,7,9,11-12H2,1-2H3/t15-,16+,18?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443080 (CHEMBL3087514) Show SMILES COC(=O)N1C[C@@H]2CCC(O)(C#Cc3cccc(C)c3)[C@@H]2C1 |r| Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)6-8-18(21)9-7-15-11-19(12-16(15)18)17(20)22-2/h3-5,10,15-16,21H,7,9,11-12H2,1-2H3/t15-,16+,18?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438288 (CHEMBL2408575) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)nc3)nc2C1 Show InChI InChI=1S/C15H16N4O/c1-9-5-13-12(14(20)6-9)8-17-15(19-13)18-11-4-3-10(2)16-7-11/h3-4,7-9H,5-6H2,1-2H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438305 (CHEMBL2408585) Show SMILES Clc1cccc(Nc2ncc3C(=O)CCCc3n2)c1 Show InChI InChI=1S/C14H12ClN3O/c15-9-3-1-4-10(7-9)17-14-16-8-11-12(18-14)5-2-6-13(11)19/h1,3-4,7-8H,2,5-6H2,(H,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438291 (CHEMBL2408572) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(OC(F)F)cc3)nc2C1 Show InChI InChI=1S/C16H15F2N3O2/c1-9-6-13-12(14(22)7-9)8-19-16(21-13)20-10-2-4-11(5-3-10)23-15(17)18/h2-5,8-9,15H,6-7H2,1H3,(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443079 (CHEMBL3087225) Show SMILES CN(C)C(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,TLB:3:5:10.11.13:7.8| Show InChI InChI=1S/C19H24N2O2/c1-14-5-4-6-15(11-14)9-10-19(23)12-16-7-8-17(13-19)21(16)18(22)20(2)3/h4-6,11,16-17,23H,7-8,12-13H2,1-3H3/t16-,17+,19+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443078 (CHEMBL3087509) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@@](C2)(OC)C#Cc1cccc(C)c1 |r,TLB:2:4:9.10.11:6.7| Show InChI InChI=1S/C19H23NO3/c1-14-5-4-6-15(11-14)9-10-19(23-3)12-16-7-8-17(13-19)20(16)18(21)22-2/h4-6,11,16-17H,7-8,12-13H2,1-3H3/t16-,17+,19+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438293 (CHEMBL2408570) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C#N)c(F)c3)nc2C1 Show InChI InChI=1S/C16H13FN4O/c1-9-4-14-12(15(22)5-9)8-19-16(21-14)20-11-3-2-10(7-18)13(17)6-11/h2-3,6,8-9H,4-5H2,1H3,(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443077 (CHEMBL3087505) Show SMILES CN(C)C(=N/C#N)\N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,TLB:3:7:12.13.15:9.10| Show InChI InChI=1S/C20H24N4O/c1-15-5-4-6-16(11-15)9-10-20(25)12-17-7-8-18(13-20)24(17)19(22-14-21)23(2)3/h4-6,11,17-18,25H,7-8,12-13H2,1-3H3/b22-19+/t17-,18+,20+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	168	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438298 (CHEMBL2408565) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1 Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438298 (CHEMBL2408565) Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1 Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443076 (CHEMBL3087507) Show SMILES Cc1cccc(c1)C#C[C@@]1(O)C[C@@H]2CC[C@H](C1)N2c1ncccc1C#N |r,TLB:18:17:16.9.11:13.14| Show InChI InChI=1S/C22H21N3O/c1-16-4-2-5-17(12-16)9-10-22(26)13-19-7-8-20(14-22)25(19)21-18(15-23)6-3-11-24-21/h2-6,11-12,19-20,26H,7-8,13-14H2,1H3/t19-,20+,22+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443075 (CHEMBL3086717) Show SMILES COC(=O)N1CC(F)(F)C(O)(C#Cc2cccc(C)c2)[C@@H]2CCC[C@H]12 |r| Show InChI InChI=1S/C19H21F2NO3/c1-13-5-3-6-14(11-13)9-10-18(24)15-7-4-8-16(15)22(17(23)25-2)12-19(18,20)21/h3,5-6,11,15-16,24H,4,7-8,12H2,1-2H3/t15-,16+,18?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443074 (CHEMBL3087218) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(c1)C#N |r,TLB:2:4:9.10.12:6.7| Show InChI InChI=1S/C18H18N2O3/c1-23-17(21)20-15-5-6-16(20)11-18(22,10-15)8-7-13-3-2-4-14(9-13)12-19/h2-4,9,15-16,22H,5-6,10-11H2,1H3/t15-,16+,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443073 (CHEMBL3086716) Show SMILES COC(=O)N1CCC(O)(C#Cc2cccc(C)c2)[C@H]2CCC[C@@H]12 |r| Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)9-10-19(22)11-12-20(18(21)23-2)17-8-4-7-16(17)19/h3,5-6,13,16-17,22H,4,7-8,11-12H2,1-2H3/t16-,17+,19?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443072 (CHEMBL3087226) Show SMILES Cc1cccc(c1)C#C[C@@]1(O)C[C@@H]2CC[C@H](C1)N2C(=O)N1CCC1 |r,TLB:18:17:16.9.11:13.14| Show InChI InChI=1S/C20H24N2O2/c1-15-4-2-5-16(12-15)8-9-20(24)13-17-6-7-18(14-20)22(17)19(23)21-10-3-11-21/h2,4-5,12,17-18,24H,3,6-7,10-11,13-14H2,1H3/t17-,18+,20+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443071 (CHEMBL3086718) Show SMILES COC(=O)N1CCC(O)(C#Cc2cccc(C)c2)C2CCCCC12 Show InChI InChI=1S/C20H25NO3/c1-15-6-5-7-16(14-15)10-11-20(23)12-13-21(19(22)24-2)18-9-4-3-8-17(18)20/h5-7,14,17-18,23H,3-4,8-9,12-13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438300 (CHEMBL2408563) Show SMILES CC1(C)CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1 Show InChI InChI=1S/C16H16ClN3O/c1-16(2)7-13-12(14(21)8-16)9-18-15(20-13)19-11-5-3-10(17)4-6-11/h3-6,9H,7-8H2,1-2H3,(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438303 (CHEMBL2408561) Show SMILES O=C1CCCc2nc(Nc3cccc(c3)C#N)ncc12 Show InChI InChI=1S/C15H12N4O/c16-8-10-3-1-4-11(7-10)18-15-17-9-12-13(19-15)5-2-6-14(12)20/h1,3-4,7,9H,2,5-6H2,(H,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	272	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443070 (CHEMBL3087213) Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1ccccc1 |r,TLB:2:4:9.10.12:6.7| Show InChI InChI=1S/C17H19NO3/c1-21-16(19)18-14-7-8-15(18)12-17(20,11-14)10-9-13-5-3-2-4-6-13/h2-6,14-15,20H,7-8,11-12H2,1H3/t14-,15+,17+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	298	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443069 (CHEMBL3086719) Show SMILES COC(=O)N1CCC2(CC(O)(C2)C#Cc2cccc(C)c2)CC1 Show InChI InChI=1S/C19H23NO3/c1-15-4-3-5-16(12-15)6-7-19(22)13-18(14-19)8-10-20(11-9-18)17(21)23-2/h3-5,12,22H,8-11,13-14H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	306	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443068 (CHEMBL3087224) Show SMILES Cc1cccc(c1)C#C[C@@]1(O)C[C@@H]2CC[C@H](C1)N2C(=O)C(C)(C)C |r,TLB:18:17:16.9.11:13.14| Show InChI InChI=1S/C21H27NO2/c1-15-6-5-7-16(12-15)10-11-21(24)13-17-8-9-18(14-21)22(17)19(23)20(2,3)4/h5-7,12,17-18,24H,8-9,13-14H2,1-4H3/t17-,18+,21+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	308	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443067 (CHEMBL3087211) Show SMILES COC(=O)N1CCC(O)(CC11CCC1)C#Cc1cccc(C)c1 Show InChI InChI=1S/C19H23NO3/c1-15-5-3-6-16(13-15)7-10-19(22)11-12-20(17(21)23-2)18(14-19)8-4-9-18/h3,5-6,13,22H,4,8-9,11-12,14H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438281 (CHEMBL2408408) Show SMILES Clc1cccc(Nc2ncc3CCCCc3n2)c1 Show InChI InChI=1S/C14H14ClN3/c15-11-5-3-6-12(8-11)17-14-16-9-10-4-1-2-7-13(10)18-14/h3,5-6,8-9H,1-2,4,7H2,(H,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	452	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438301 (CHEMBL1389853) Show SMILES Cc1ccc(Nc2ncc3C(=O)CC(C)(C)Cc3n2)cc1 Show InChI InChI=1S/C17H19N3O/c1-11-4-6-12(7-5-11)19-16-18-10-13-14(20-16)8-17(2,3)9-15(13)21/h4-7,10H,8-9H2,1-3H3,(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	492	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438299 (CHEMBL2408564) Show SMILES CC1(C)CC(=O)c2cnc(Nc3ccc(cc3)C#N)nc2C1 Show InChI InChI=1S/C17H16N4O/c1-17(2)7-14-13(15(22)8-17)10-19-16(21-14)20-12-5-3-11(9-18)4-6-12/h3-6,10H,7-8H2,1-2H3,(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	493	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50438309 (CHEMBL2408582) Show SMILES Cc1cccc(Nc2ncc3C(=O)CCCc3n2)c1 Show InChI InChI=1S/C15H15N3O/c1-10-4-2-5-11(8-10)17-15-16-9-12-13(18-15)6-3-7-14(12)19/h2,4-5,8-9H,3,6-7H2,1H3,(H,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	496	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...				Bioorg Med Chem Lett 23: 4493-500 (2013) Article DOI: 10.1016/j.bmcl.2013.06.049 BindingDB Entry DOI: 10.7270/Q2KD20B8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443066 (CHEMBL3087223) Show SMILES CC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,TLB:1:3:8.9.11:5.6| Show InChI InChI=1S/C18H21NO2/c1-13-4-3-5-15(10-13)8-9-18(21)11-16-6-7-17(12-18)19(16)14(2)20/h3-5,10,16-17,21H,6-7,11-12H2,1-2H3/t16-,17+,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	543	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50443065 (CHEMBL3087506) Show SMILES Cc1cccc(c1)C#C[C@@]1(O)C[C@@H]2CC[C@H](C1)N2S(C)(=O)=O |r,TLB:18:17:16.9.11:13.14| Show InChI InChI=1S/C17H21NO3S/c1-13-4-3-5-14(10-13)8-9-17(19)11-15-6-7-16(12-17)18(15)22(2,20)21/h3-5,10,15-16,19H,6-7,11-12H2,1-2H3/t15-,16+,17+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
Merz Pharmaceuticals GmbH Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...				Bioorg Med Chem Lett 23: 6370-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.059 BindingDB Entry DOI: 10.7270/Q2W37XRD
					More data for this Ligand-Target Pair

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