BindingDB PrimarySearch

Found 15 hits with Last Name = 'abriel' and Initial = 'h'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM96504 (4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)b...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526037 (CHEMBL4439848) Show SMILES Cc1cccc(NC(=O)COc2ccccc2Cl)c1C(O)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526038 (CHEMBL4525597) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)COc1ccccc1Cl Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526034 (CHEMBL4540384) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526040 (CHEMBL4447880) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526032 (CHEMBL4574460) Show SMILES OC(=O)c1ccc(cc1NC(=O)COc1ccccc1Cl)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526035 (CHEMBL4472038) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526036 (CHEMBL4554529) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526039 (CHEMBL4465106) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50350791 (LEVOBUPIVACAINE HYDROCHLORIDE) Show SMILES CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of wild-type human ERG channel expressed in CHO cells by whole-cell patch clamp technique				Eur J Med Chem 46: 3486-98 (2011) Article DOI: 10.1016/j.ejmech.2011.05.015 BindingDB Entry DOI: 10.7270/Q2TD9XQ6
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50350791 (LEVOBUPIVACAINE HYDROCHLORIDE) Show SMILES CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...				Eur J Med Chem 46: 3486-98 (2011) Article DOI: 10.1016/j.ejmech.2011.05.015 BindingDB Entry DOI: 10.7270/Q2TD9XQ6
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50350790 (BUPIVACAINE HYDROCHLORIDE \| Bupivacaine \| SAMPL3, ...) Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of wild-type human ERG channel expressed in CHO cells by whole-cell patch clamp technique				Eur J Med Chem 46: 3486-98 (2011) Article DOI: 10.1016/j.ejmech.2011.05.015 BindingDB Entry DOI: 10.7270/Q2TD9XQ6
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 4 (Homo sapiens)	BDBM50526033 (CHEBI:28820 \| CHEMBL2407182) Show SMILES Oc1cc2ccccc2c2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Berne Curated by ChEMBL					Assay Description Inhibition of TRPM4 (unknown origin)				Eur J Med Chem 166: 167-177 (2019) Article DOI: 10.1016/j.ejmech.2019.01.048 BindingDB Entry DOI: 10.7270/Q2GH9NCB
University of Berne Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50350790 (BUPIVACAINE HYDROCHLORIDE \| Bupivacaine \| SAMPL3, ...) Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...				Eur J Med Chem 46: 3486-98 (2011) Article DOI: 10.1016/j.ejmech.2011.05.015 BindingDB Entry DOI: 10.7270/Q2TD9XQ6
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50350789 (BUPIVACAINE \| CHEMBL189827) Show SMILES CCCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Geneva Curated by ChEMBL					Assay Description Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...				Eur J Med Chem 46: 3486-98 (2011) Article DOI: 10.1016/j.ejmech.2011.05.015 BindingDB Entry DOI: 10.7270/Q2TD9XQ6
University of Geneva Curated by ChEMBL					More data for this Ligand-Target Pair